Yes! You can use a hardware wallet. NOTE: If you're using a Ledger, make sure the Cardano app is on the latest version of ledger live! (currently 5.0.1)

PLEASE NOTE: Hardware wallets (as of this writing) cannot be used for anything that requires SignData (essentially signing with your wallet, but without any ADA being transacted). This would include creating collections, making counter offers, creating profiles, etc.